The aim of the present investigation was to develop controlled release matrix tablet formulations of metformin hydrochloride using Chitosan and Eudragit L100 polymer alone and in combination at different concentrations and to evaluate in vitro release characteristics. Metformin HCL, a biguanide has relatively short plasma half life, low absolute bioavailability. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Hydrophilic matrix of Chitosan alone could not control the Metformin release effectively for 12 h whereas when combined with Eudragit L100 could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets. Swelling studies were also carried out. Fitting the data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.
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